Obesity & Diabetes
F-DIO obesity-prone rat is insulin resistant before obesity onset
Published in Obesity and Diabetes Week, November 21st, 2005
According to recent research from the United States and France, "We previously created a novel F-DIO rat strain derived by crossing rats selectively bred for the diet-induced obesity (DIO) phenotype with obesity-resistant Fischer F344 rats. The offspring retained the DIO phenotype through three backcrosses with F344 rats but also had exaggerated insulin responses to oral glucose before they became obese on a 31% fat high-energy (HE) diet."
"Here, we demonstrate that chow-fed rats from the subsequent randomly bred progeny required 57% lower glucose infusions to maintain...
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