Published in Obesity and Diabetes Week, November 28th, 2005
"Thioredoxin-interacting protein (TXNIP) is overexpressed in diabetes and has deleterious effects on pancreatic beta-cells and the cardiovascular system. TXNIP is a regulator of the cellular redox state, but has also been suggested to act as a transcriptional repressor," scientists in the United States report.
A.H. Minn and colleagues at the University of Wisconsin remarked, "the genes and pathways regulated by TXNIP remain unknown. We, therefore, compared gene expression in INS-1 insulinoma beta-cells overexpressing TXNIP and control...
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