Genetics & Genomics
TXNIP modulates overall gene transcription and may impair insulin secretion
Published in Obesity and Diabetes Week, November 28th, 2005
"Thioredoxin-interacting protein (TXNIP) is overexpressed in diabetes and has deleterious effects on pancreatic beta-cells and the cardiovascular system. TXNIP is a regulator of the cellular redox state, but has also been suggested to act as a transcriptional repressor," scientists in the United States report.
A.H. Minn and colleagues at the University of Wisconsin remarked, "the genes and pathways regulated by TXNIP remain unknown. We, therefore, compared gene expression in INS-1 insulinoma beta-cells overexpressing TXNIP and control...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Obesity and Diabetes Week
More Articles from Obesity and Diabetes Week
- Atherothrombosis Risk Factors
High rates of obesity and diabetes found in atherothrombosis patients - Disease Associations
SHIP2 is therapeutic target for treatment of both obesity and type 2 diabetes - Fitness & Wellness
Exercise decreases visceral and subcutaneous abdominal fat, inactivity raises fat levels - Pediatric Obesity
Endothelial inflammation in children linked to insulin resistance, lipid levels and BMI - Weight Loss
An obese, insulin-resistant, and/or IGT state promotes IL-6 release after high-fat meals - Alcohol Use
Higher serum DHEAS levels are found in type 2 diabetes patients who are drinkers - More from this issue of Obesity and Diabetes Week
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
