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Obesity and Diabetes Week

Susan Hasty, Publisher

Table of Contents . . . December 5th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Obesity and Diabetes Week | Other Publications

Diabetes Control - Blood glucose levels in diabetic youth should be measured frequently

Diabetes Control - Hormone modifications may improve therapeutic potential for diabetes management

Fitness & Wellness - Low fitness level is associated with increased risk of CVD mortality in diabetic men

Genetics & Genomics - Children of type 2 diabetics with the haplotype PPARGC1A are at increased risk for diabetes

Obesity Epidemiology - Distribution of waist measurements in youth are used to define pediatric abdominal obesity

Adverse Drug Reaction - Combination of metformin or thiazolidinediones and insulin in diabetes therapy is studied

Adverse Drug Reactions - Vildagliptin is effective in improving glycemic control for type 2 diabetics

Anesthesia - Morbidly obese patients respond equally to desflurane or sevoflurane when concentration is controlled

Angiology - FMD and intima-media complex data can predict vascular complications in youth

Anti-Infectives - Dutch biotech teams up with ACE BioSciences and Harvard to accelerate bacterial antibody program

Awards - Research award presented for protein therapeutics system for diabetes

Diabetes Therapy - New findings in the area of diabetes therapy described

Behavioral Medicine - Behavioral risk factors leading to obesity are reviewed

Cancer Epidemiology - Increased BMI is associated with higher risk of pancreatic cancer in men

Cancer Risk Factors - Behavioral and environmental risk factors play a major role in global cancer deaths

Cardiac Surgery Risk Factors - Hyperglycemia is independent risk factor for mortality for cardiac surgery patients

Cardiovascular Disease - G allele in adiponectin gene at SNP 276 may indicate higher CV disease risk

Cardiovascular Disease Risk Factors - Metabolic syndrome and diabetes treatment is important for cardiovascular risk control

Diabetes Therapy - Reports advance knowledge in diabetes therapy research

Childhood Obesity - Data advance knowledge in childhood obesity research

Chronic Kidney Disease - ISN is pioneering the timely prevention of chronic kidney disease in Latin America

Complementary & Alternative Medicine - Lifestyle program for hypertensive therapy lowers patient weight and cardiovascular risk

Complementary & Alternative Medicine - Palm vitamin E is more potent than alpha-tocopherol in improving dermal wound healing

Diabetes Complications - Anti-infective therapy for foot ulcers in patients with diabetes requires special care

Diabetes Complications - Antioxidative therapy in pregnant diabetic rats reduces embryonic dysmorphogenesis

Obesity Pathogenesis - Reports advance knowledge in obesity pathogenesis research

Diabetes Complications - DM does not affect postoperative result for coronary bypass surgery in multivessel disease

Diabetes Complications - Link between myocardial perfusion SPECT and severe CAD is modified by LVH and diabetes

Diabetes Complications - Macular edema and ischemia are linked to visual acuity after intravitreal triamcinolone dose

Diabetes Complications - Plasma IL-6 concentration is inversely related to insulin sensitivity and lipid metabolism

Diabetes Complications - Proper care can reduce formation and complications associated with diabetic foot

Diabetes Complications - Reduction in 14-3-3 zeta expression induces PKC activation and may cause visual impairment

Diabetes Complications - Stress 99mTc-tetrofosmin myocardial perfusion imaging is linked to higher mortality

Diabetes Complications - Survey shows nearly 70% of diabetics polled report having high blood pressure

Diabetes Complications - Type 1 and type 2 diabetes are linked to increased fracture risk

Diabetes Complications - Undiagnosed DM increases risks associated with coronary artery bypass grafting

Diabetes Control - Data show most type 2 diabetics fail to control their blood sugar

Diabetes Control - GLP-1 reduces insulin clearance in mouse model

Diabetes Control - Pedometer-registered activity is linked to aerobic capacity and self-reported fitness

Diabetes Control - Study reveals that type 2 diabetics respond better to once-daily treatments

Diabetes Epidemiology - HMW adiponectin is not linked to endothelium-dependent vasodilation in diabetic offspring

Diabetes Epidemiology - Incidence of childhood diabetes in New South Wales has risen since 1990

Diabetes Epidemiology - Inflammatory properties of LDL- in diabetics are related to increased PAF-AH activity

Diabetes Epidemiology - Left ventricular abnormalities could be a screening target for type 2 diabetics

Diabetes Epidemiology - Low rates of public enterovirus infection increase youth type 1 diabetes risk

Diabetes Epidemiology - PPARGC1A polymorphisms are associated with early-onset type 2 diabetes mellitus

Diabetes Epidemiology - Polymorphisms in gene encoding Kruppel-like factor 7 are linked to type 2 diabetes

Diabetes Epidemiology - Report shows number suffering from diabetes likely to triple by 2025

Diabetes Epidemiology - SLC12A3 +78A(+) genotype is linked to lower albumin levels and nephropathy risk

Diabetes Epidemiology - Score statistic tests genetic correlation in proband-family design

Diabetes Epidemiology - Streptozotocin-induced diabetes in rat is linked to enhanced tissue H2 S biosynthesis

Diabetes Epidemiology - TNF and LTA variants are unlikely to be involved in type 2 diabetes risk

Diabetes Epidemiology - Uncoupling protein 2 Ala55Val polymorphism is associated with diabetes mellitus

Diabetes Pathogenesis - CREB coactivator TORC2 is key regulator of fasting glucose metabolism

Diabetes Pathogenesis - Diabetic nephropaths exhibit increased glomerular and extracellular malondialdehyde levels

Diabetes Pathogenesis - New data illuminates research in diabetes pathogenesis

Diabetes Pathogenesis - Vitamin D deficiency may be involved in the pathogenesis of type 1 and type 2 diabetes

Diabetes Pathogenesis - cPLA2 alpha plays a protective role in autoimmune diabetes development

Diabetes Pathology - Fem1b inactivation leads to abnormal glucose homeostasis and pancreatic islet function

Diabetes Research - Glycosphingolipids may be associated with type 1 and type 2 diabetes

Diabetes Therapy - Data advance knowledge in diabetes therapy research

Diabetes Therapy - Diabetic rat model indicates oral magnesium doses may help relieve diabetes symptoms

Diabetes Therapy - Drug target proposed in Cdk5-dependent regulation of glucose-stimulated insulin secretion

Diabetes Therapy - Evidence supports first non-injectable insulin as alternative treatment for diabetes

Diabetes Therapy - Exenatide-LAR enhanced glucose control in diabetic fatty Zucker rat model

Diabetes Therapy - Exendin-4 has beneficial effects on islet transplantation

Diabetes Therapy - Family physician organization receives 3-year grant for diabetes care

Diabetes Therapy - Novel albumin-insulin conjugate releases insulin slowly under physiological conditions

Diabetes Therapy - Some foods, beverages could hold clues for future diabetes treatment

Diabetic Nephropathy - Research in diabetic nephropathy provides new insights

Diabetic Wounds - New wound score is developed for improved evaluation of diabetic wounds

Diagnostics - Asymptomatic bacteriuria is predictor of increased urosepsis risk in diabetics

Diagnostics - More adolescent bariatric surgery evaluations are needed to make appropriate decision

Diet & Nutrition - Conjugated fatty acids in food have anticancer, antiobese, and antidiabetic effects

Diet & Nutrition - Diet and weight loss do not affect cell proliferation biomarkers in Barrett esophagus

Diet & Nutrition - Fatty acid composition of serum lipids predicts development of metabolic syndrome in men

Diet & Nutrition - Higher diverse diet could decrease risk for some metabolic disorders

Diet & Nutrition - Literature review finds low-carb may be better than low-fat diet for metabolic syndrome

Diet & Nutrition - Poor fetal growth followed by rapid postnatal catch-up growth leads to early mortality

Diet & Nutrition - Rapid early weight gain, obesity, and early puberty may increase risk of health problems

Diet & Nutrition - Replacing some carbohydrates with protein and unsaturated fat may enhance heart health benefits

Disease Associations - Diabetics exhibit normal metabolism of apolipoprotein B100-containing lipoproteins

Disease Associations - Effect of fatty acid metabolism on cardiovascular disease and diabetes risk is reviewed

Disease Associations - Survivors of lymphoblastic leukemia have higher total body fat and poor lipid profile

Drug Delivery - Novel elementary osmotic pump developed for multidrug delivery therapy of type 2 diabetes

Drug Development - Additional drug targets selected for diabetes and obesity from gene database

Drug Development - Inhibition of MT1-MMP interferes with diabetogenic T cell homing in the pancreas

Epidemiology - Early childhood BMI does not drive early menarche and continued obesity

Finance - Macugen maker reports third-quarter 2005 financial results: net income $2.8M

Finance - Pharma company reports total revenue of $36.4 million

Finance - Weight loss services company reports Q3 2005 consolidated net revenues up 5%

Fitness & Wellness - After-school program teaching nutrition and physical activity now available nationally

Fitness & Wellness - Exercise intensity of 30% heart rate reserve is recommended for overweight subjects

Gastroenterology - Laparoscopic study reveals weight loss but high esophagitis incidence

Generic Drugs - U.S. FDA grants approval of generics for type 2 diabetes

Genetics & Genomics - ADIPOR1 or ADIPOR2 polymorphisms unlikely to be linked to increased type 2 diabetes risk

Genetics & Genomics - Haplotypes in PLTP gene are associated with obesity-related phenotypes

Genetics & Genomics - Mutations in arginine vasopressin gene indicate genotype-phenotype correlation in FNDI

Genetics & Genomics - PCK1 polymorphisms are associated with high-density lipoprotein and triglyceride levels

Health Promotion - Treatment options for obese patients are reviewed

Healthcare Costs - Depression in diabetics increases health services costs 50-75%

Imaging - Imaging company launches fluoroscopy system to accommodate bariatric patients

Information Technology - New web site features clinical biomarker research

Insulin - Insulin acutely decreases hepatic fatty acid synthase activity

Medical Devices - Autolet Impression lancing device delivers improved levels of comfort, control

Medical Devices - BIB is an effective method for weight loss and improves comorbidities after 6 months

Mental Health - Medicaid telephone screening identifies depressed diabetes and heart failure patients

Mergers & Acquisitions - Access Diabetic Supply acquires operating assets, expands customer base

Mergers & Acquisitions - Acquisition of obesity treatment provider Sound Health Solutions announced

Obesity Complications - Hyperviscosity in obese school children is related to subclinical atherosclerosis

Obesity Complications - Obesity is linked to increased CV risk and proteinuria progression in transplant patients

Obesity Complications - Obesity is not a contraindication to laparoscopic Nissen fundoplication

Obesity Epidemiology - The metabolic syndrome and independent factors of the syndrome are heritable

Obesity Epidemiology - WHO class-specific equations using height2 was developed for predicting body weight

Obesity Pathogenesis - Findings advance knowledge in obesity pathogenesis research

Obesity Pathogenesis - MC4R may be needed for obesity-related hypertension, hyperleptinemia, or hyperinsulinemia

Obesity Pathogenesis - Plasma palmitoleic acid content is related to abdominal adiposity in obese children

Obesity Risk Factors - Study finds that inadequate sleep is a risk factor for obesity

Obesity Surgery - Researchers' data advance obesity surgery research

Obesity and Diabetes - New findings in obesity and diabetes described

Pediatric Diabetes - Circulating acylated and total ghrelin levels may be linked to BMI in diabetic children

Pediatric Obesity - Childhood obesity has long-term impacts on cardiovascular and general health

Pediatrics Diabetes - Treatment of diabetic children involves glycemic control and assessing family dynamics

Pharmaceutical Research - Alendronate improves osteopenia after gastrectomy-treated gastric cancer patients

Pharmaceutical Research - Pioglitazone protects obese, insulin resistant mice against arterial thrombosis

Prognostics - Insulin resistance is the main predictor of nonalcoholic steatohepatitis

Surgical Technology - Novel sternal closure technique prevents dehiscence in obese patients

Transplant Medicine - Transplant of WAT into mice guards against obesity, insulin resistance and infertility

Type 1 Diabetes - Age, metabolic control, and insulin regime influences HRQOL in diabetic youth

Type 1 Diabetes - Diabetes monocytes show raised MRP8/14 expression and reduced migration towards chemokines

Type 1 Diabetes - Interim results encouraging in animal pancreatic xenotransplantation study

Type 1 Diabetes - Self-management program can improve glycemic control without impaired hypoglycemic risk

Type 2 Diabetes - 1267 HSP70-2 polymorphism may indicate carotid plaque rupture and cerebral ischemia risk

Type 2 Diabetes - Inhibition of adipose tissue lipolysis increases intramuscular lipid use in diabetics

Type 2 Diabetes - Obese children and adolescents have a higher incidence of glucose intolerance

Type 2 Diabetes Therapy - Survey shows 86% of patients with type 2 diabetes want therapy changes

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