Diabetes Therapy
Drug target proposed in Cdk5-dependent regulation of glucose-stimulated insulin secretion
Published in Obesity and Diabetes Week, December 5th, 2005
"Tight glycemic control in individuals with diabetes mellitus is essential to prevent or delay its complications. Present treatments to reduce hyperglycemia mainly target the ATP-sensitive K+ (KATP ) channel of pancreatic beta cells to increase insulin secretion. These current approaches are often associated with the side effect of hypoglycemia," investigators in Japan report.
F.Y. Wei and colleagues at Okayama University demonstrated "that inhibition of the activity of cyclin-dependent kinase 5 (Cdk5) enhanced insulin secretion...
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