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Obesity Epidemiology

Palmitate induces inflammation in adipocytes through NF-kappaB, IL-6 and TNF-alpha

Published in Obesity and Diabetes Week, December 12th, 2005

Palmitate induces inflammation in adipocytes by activating the nuclear factor kappaB transcription factor and inducing interleukin-6 and TNF-alpha expression.

According to a study from the United States, "Fatty acids and their metabolites regulate gene expression and immunological pathways. Furthermore, obese individuals frequently have increased circulating fatty acid concentrations, and localized inflammation in adipose tissue may facilitate the systemic inflammation associated with the insulin resistance of obesity."

K.M. Ajuwon and M.E. Spurlock from Purdue University remarked, "Although palmitate induces inflammation (i.e., activates...

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