Obesity Therapy
Melanocortin-4 receptor antagonist AGRP may be a therapeutic target for obesity treatment
Published in Obesity and Diabetes Week, December 12th, 2005
According to a recent review from England, "It is well established that agouti-related protein (AGRP) can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement."
L.E. Pritchard and A. White at the University of Manchester remarked, "[T]here are clearly additional facets to the physiological role of AGRP, given that it is active in MC4R knockout...
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