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Diabetes Complications

Urinary tyrosine levels may signify renal impairment in diabetes and renal failure patients

Published in Obesity and Diabetes Week, December 12th, 2005

Urinary ortho-tyrosine levels may indicate renal impairment in diabetes mellitus and renal failure patients.

According to a study from Hungary, "Phenylalanine is converted to para-and ortho-tyrosine by hydroxyl free radical, or to para-tyrosine by the phenylalanine hydroxylase enzyme. The aim of this study was to measure para-and ortho-tyrosine in the urine and plasma of patients with chronic renal disease and/or diabetes, to obtain information on the renal handling of the different tyrosine isomers and, furthermore, to measure urinary levels of 8-epi-prostaglandin-F2 alpha, a marker of lipid peroxidation."

G.A. Molnar and colleagues at...

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