Diabetes Pathogenesis
Amadori-PE analysis reveals link between lipid glycation and peroxidation in diabetes
Published in Obesity and Diabetes Week, December 12th, 2005
According to recent research from Japan, "Peroxidized phospholipid-mediated cytotoxicity is involved in the pathophysiology of diseases [i.e. an abnormal increase of phosphatidylcholine hydroperoxide (PCOOH) in plasma of type 2 diabetic patients]. The PCOOH accumulation may relate to Amadori-glycated phosphatidylethanolamine (Amadori-PE; deoxy-d-fructosyl phosphatidylethanolamine), because Amadori-PE causes oxidative stress."
"However," remarked K. Nakagawa and colleagues at Tohoku...
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