Diabetes Pathogenesis
Diabetic rat model shows oxidative and nitrosative stress may cause neuronal cell injury
Published in Obesity and Diabetes Week, December 12th, 2005
"Diabetic encephalopathy, characterized by impaired cognitive functions and neurochemical and structural abnormalities, may involve direct neuronal damage caused by intracellular glucose. The study assesses the direct effect of chronic hyperglycemia on the function of brain mitochondria, the major site of reactive species production, in diabetic streptozotocin (STZ) rats. Oxidative stress plays a central role in diabetic tissue damage," investigators in Italy report.
R. Mastrocola and colleagues at the University of Turin...
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