Obesity Epidemiology
Gly482Ser polymorphism in PPARGC1 links obese variances observed in metabolic syndrome
Published in Obesity and Diabetes Week, December 12th, 2005
"Factors influencing the severity of the metabolic syndrome among obese subjects or the conversion to cardiovascular disease or type 2 diabetes (T2D) remain largely unknown, but there is strong evidence for genetic susceptibilities. Peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1) is a transcriptional coactivator of many nuclear receptors including PPAR-gamma, involved in the regulation of fatty acid oxidation, skeletal muscle fiber type specificity, and gluconeogenesis," scientists in Canada...
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