Diet & Nutrition
Norepinephrine- and epinephrine-deficient mice gain weight normally on high-fat diet
Published in Obesity and Diabetes Week, December 12th, 2005
"Signaling through adrenergic receptors (ARs) by norepinephrine (NE) and epinephrine (Epi) regulates weight gain when mice are fed a high-fat diet (HFD) by controlling diet-induced thermogenesis. Thus, one would predict that mice unable to make NE/Epi because of inactivation of the dopamine beta-hydroxylase gene (Dbh-null mice) would have a propensity to become obese," investigators in the United States report.
L.S. Marie and colleagues at the University of Washington in Seattle examined "the response of Dbh-null and control mice to a HFD.Dbh-null and control...
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