Type 2 Diabetes
Poly(ADP-ribose)polymerase activity is lower in circulating MNCs from diabetics
Published in Obesity and Diabetes Week, December 26th, 2005
"Poly(ADP-ribose)polymerase (PARP-1), a nuclear enzyme activated by DNA strand breaks, is involved in DNA repair, aging, inflammation, and neoplastic transformation. In diabetes, reactive oxygen and nitrogen species occurring in response to hyperglycemia cause DNA damages and PARP-1 activation," investigators in Italy report.
I. Tempera and colleagues, Policlinico Umberto I, explained, "Because circulating mononuclear cells (MNCs) are involved in inflammation mechanisms, these cells were chosen as the experimental model to evaluate PARP-1...
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