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Diabetes Complications

High glucose conditions increased synthesis of TSP-1 and NPY in myocardium of rat model

Published in Obesity and Diabetes Week, December 26th, 2005

High glucose conditions can induce an increased synthesis of thrombospondin-1 and neuropeptide Y in myocardium of STZ-induced rats.

"Diabetic cardiomyopathy was the most dangerous diabetic complication facing diabetics, with its exact mechanisms remaining obscure. Our study was conducted to investigate the expression of thrombospondin-1 (TSP-1) and neuropeptide Y (NPY) in myocardium of streptozotocin (STZ)-induced diabetic rats," researchers in People's Republic of China report.

X.M. Zhang and colleagues at Zhejiang University in Hangzhou employed "streptozotocin (STZ)-induced diabetic rats to study the alteration of the TSP-1 and NPY expression in...

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