Diabetic Retinopathy
Endothelial maneuvers overshadow pericyte coverage during retinal capillary maturation
Published in Obesity and Diabetes Week, December 26th, 2005
"Pericyte loss and capillary regression are characteristic for incipient diabetic retinopathy. Pericyte recruitment is involved in vessel maturation, and ligand-receptor systems contributing to pericyte recruitment are survival factors for endothelial cells in pericyte-free in vitro systems," investigators in Germany report.
"We studied pericyte recruitment in relation to the susceptibility toward hyperoxia-induced vascular remodeling using the pericyte reporter X-LacZ mouse and the mouse model of retinopathy of prematurity (ROP). Pericytes were found in close...
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