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Diabetes Complications

Diabetic rat hearts exhibit altered local Ca2+ signaling with increased basal Ca2+ levels

Published in Obesity and Diabetes Week, January 2nd, 2006

Streptozotocin-induced diabetic rat hearts exhibit altered local Ca2+ signaling with increased basal Ca2+ levels.

According to recent research from Turkey, "The defects identified in the mechanical activity of the hearts from type 1 diabetic animals include alteration of Ca2+ signaling via changes in critical processes that regulate intracellular Ca2+ concentration. These defects result partially from a dysfunction of cardiac ryanodine receptor calcium release channel (RyR2)."

N. Yaras and colleagues at Ankara University designed the current investigation "to determine whether the properties of the...

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