Diabetes Pathogenesis
Lower catecholamine-induced lipolysis and HSL expression are linked to obesity
Published in Obesity and Diabetes Week, January 2nd, 2006
"The mobilization of fat stored in adipose tissue is mediated by hormone-sensitive lipase (HSL) and the recently characterized adipose triglyceride lipase (ATGL), yet their relative importance in lipolysis is unknown. We show that a novel potent inhibitor of HSL does not inhibit other lipases," researchers in France report.
D. Langin and colleagues working with the Institut National de la Sante et de la Recherche Medicale determined, "The compound counteracted catecholamine-stimulated lipolysis in mouse adipocytes and...
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