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Diabetes Pathogenesis

The mechanisms behind diabetes and hypertension onset in hereditary obesity are presented

Published in Obesity and Diabetes Week, January 2nd, 2006

Hereditary obesity can result in downregulations of kidney NO synthases and glomerulosclerosis prior to the onset of frank diabetes and hypertension.

According to a study from the United States, "Obesity has emerged as a major cause of diabetes, cardiovascular disease, and renal insufficiency worldwide. Obese Zucker rats exhibit hyperphagia, obesity, insulin resistance, hyperlipidemia, and glomerulosclerosis and are frequently used as a model to study hereditary form of metabolic syndrome. Nitric oxide plays a major role in preservation of renal function and structure."

Z. Li and colleagues working with the University of California Irvine explained,...

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