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Genetics & Genomics

Diabetic nephropathy risk in men is linked to polymorphisms in RANTES receptor gene

Published in Obesity and Diabetes Week, January 9th, 2006

Risk of diabetic nephropathy in men, not women, with type 1 diabetes is associated with functional polymorphisms in RANTES receptor gene.

"Chemokines and their receptors have been implicated in the development of diabetic nephropathy. To determine whether the risk of diabetic nephropathy is influenced by two functional polymorphisms in the regulated upon activation normal T-cell expressed and secreted (RANTES) receptor gene (CCR5), we recruited patients with type 1 diabetes, including 496 case subjects with overt proteinuria or end-stage renal disease and 298 control subjects with normoalbuminuria," scientists in the United States report.

W.M....

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