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Obesity Therapy

Polymorphisms in SLC6A2 and GRIN1 affect weight loss response of GW320659 in obese subjects

Published in Obesity and Diabetes Week, January 23rd, 2006

Polymorphisms in SLC6A2 and GRIN1 influence the weight loss response of the norepinephrine/dopamine transporter inhibitor GW320659 in obese subjects.

"GW320659, a highly selective neuronal norepinephrine and dopamine reuptake inhibitor, has been evaluated for the treatment of obesity. Scrutiny of the weight loss data from a phase II study (GlaxoSmithKline study OBS20001) showed a wide variation in weight loss response following GW320659 treatment and the possibility that the study population might include subgroups with enhanced weight loss response," scientists in England report.

C.F. Spraggs and colleagues at GlaxoSmithKline explained,...

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