Diabetes Pathogenesis
Findings describe new data in Diabetes Pathogenesis research
Published in Obesity and Diabetes Week, January 23rd, 2006
Study 1: A rat model demonstrated that brazilin raises fructose-2,6-bisphosphate levels, thereby inhibiting hepatic gluconeogenesis.
According to a study from South Korea, "Increased hepatic glucose output is one of the major mechanisms of hyperglycemia in diabetic patients. Fructose-2,6-bisphosphate (F-2,6-BP), a gluconeogenic intermediate, plays a critical role in hepatic glucose output by regulating gluconeogenesis and glycolysis in the liver. Brazilin, an active component of sappan wood (Caesalpinia sappan), decreases blood glucose in diabetic...
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