Atherosclerosis
AMPK activation by alpha-Lipoic acid prevents endothelial dysfunction in obese rats
Published in Obesity and Diabetes Week, January 23rd, 2006
According to a study from South Korea, "Lipid accumulation in vascular endothelial cells may play an important role in the pathogenesis of atherosclerosis in obese subjects. We showed previously that alpha-lipoic acid (ALA) activates AMP-activated protein kinase (AMPK) and reduces lipid accumulation in skeletal muscle of obese rats."
"Here," proposed W.J. Lee and colleagues at the University of Ulsan in Seoul, "we investigated whether ALA improves endothelial dysfunction in obese rats by activating AMPK in endothelial cells."
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