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Diabetes Pathogenesis

Inflammatory mediators by abdominal adipose tissue may link obesity and insulin resistance

Published in Obesity and Diabetes Week, January 30th, 2006

Inflammatory mediators by abdominal adipose tissue may link obesity and insulin resistance.

"The production of inflammatory mediators by abdominal adipose tissue may link obesity and insulin resistance. We determined the influence of systemic levels of interleukin-6 and C-reactive protein on insulin sensitivity after weight loss via Roux-en-Y gastric bypass surgery," researchers in the United States report.

N. Gletsu and colleagues at Emory University in Atlanta described, "Severely obese individuals (n=15) were evaluated at baseline and at 6 months after surgery. Insulin sensitivity was determined by frequently sampled intravenous glucose tolerance...

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