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Diabetes Pathogenesis

NA-induced PCK and CPI-17 activation is enhanced in arteries of diabetic rats

Published in Obesity and Diabetes Week, February 6th, 2006

Noradrenaline-induced activation of protein kinase C and CPI-17 is enhanced in arteries of diabetic rats, and mediates enhanced contractile responses.

"Protein kinase C (PKC) may contribute to enhanced contractile responses of arteries from streptozotocin-diabetic rats to stimulation of G-protein coupled receptors. This was investigated by comparing the effects of PKC inhibitors on contractile responses of mesenteric arteries from diabetic and age-matched control rats to noradrenaline (NA) and endothelin-1 (ET-1)," scientists in Canada report.

I. Mueed and colleagues at the University if British Columbia continued, "The effects of NA and ET-1 on the...

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