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Adverse Drug Reaction

Sulfonylurea drugs associated with higher mortality rate in diabetes patients

Published in Obesity and Diabetes Week, February 6th, 2006

Sulfonylurea drugs were associated with a higher mortality rate than metformin in a large study of patients with diabetes.

Sulfonylurea drugs, used in the treatment of patients with diabetes mellitus to lower blood sugar levels, have been suspected since the 1970s of increasing cardiovascular mortality as well.

In this study, some 5,800 patients treated with pills for their diabetes were monitored for an average of about 5 years. Scot H. Simpson, University of Alberta, and colleagues published their findings in the January 17, 2006, issue of the Canadian Medical Association Journal (Dose-response relation between sulfonylurea drugs and...

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