Endocrinology
Brain GLP-1 raises insulin secretion and muscle resistance to favor hepatic glycogen storage
Published in Obesity and Diabetes Week, February 6th, 2006
According to a study from France, "Intestinal glucagon-like peptide-1 (GLP-1) is a hormone released into the hepatoportal circulation that stimulates pancreatic insulin secretion. GLP-1 also acts as a neuropeptide to control food intake and cardiovascular functions, but its neural role in glucose homeostasis is unknown. We show that brain GLP-1 controlled whole-body glucose fate during hyperglycemic conditions."
C. Knauf and colleagues at the University Toulouse 3 found, "In mice undergoing a hyperglycemic hyperinsulinemic clamp,...
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