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Antipsychotics

Olanzapine reported to be associated with significantly greater weight gain than haloperidol

Published in Obesity and Diabetes Week, February 6th, 2006

Olanzapine was associated with significantly greater weight gain than haloperidol.

"Substantial weight gain is common with many atypical antipsychotics." investigators in Canada report. They designed a study "[t]o evaluate the extent, time course and predictors of weight gain and its effect on study retention among people with first-episode psychosis treated with olanzapine or haloperidol."

R.B. Zipursky and colleagues, Center for Addiction & Mental Health, explained, "Survival analysis assessed time to potentially clinically significant weight gain ({{>=}}7%) and the effect of weight gain on study retention. Weight gain during the 2-year study...

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