Obesity Pathogenesis
SHP regulates PGC-1alpha expression and energy production in brown adipocytes
Published in Obesity and Diabetes Week, February 27th, 2006
According to a study from the United States, "Brown adipocytes increase energy production in response to induction of PGC-1alpha, a dominant regulator of energy metabolism. We have found that the orphan nuclear receptor SHP (NR0B2) is a negative regulator of PGC-1alpha expression in brown adipocytes."
L. Wang and colleagues working with Baylor College of Medicine determined, "Mice lacking SHP show increased basal expression of PGC-1alpha, increased energy expenditure, and resistance to diet-induced obesity. Increased PGC-1alpha expression in SHP...
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