Diabetes Therapy
KCP256 shows lower drug-induced hypoglycemia risk compared with sulfonylurea drugs
Published in Obesity and Diabetes Week, February 27th, 2006
According to recent research published in the European Journal of Pharmacology, "The insulinotropic activity of KCP256 [(R)-8-benzyl-2-cyclopentyl-7, 8-dihydro-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one hydrochloride] was examined using MIN6 cells (a pancreatic beta-cell line) and pancreatic islets isolated from rats. Unlike sulfonylurea antidiabetic drugs, KCP256 dose-dependently (0.1-10 mcM) enhanced insulin secretion from MIN6 cells and its insulinotropic effect was exerted only at high concentrations of glucose (8.3-22 mM) but not at...
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