Obesity Pathogenesis
Loss of melanin concentrating hormone neurons can lead to acquired leanness in mice
Published in Obesity and Diabetes Week, March 6th, 2006
According to recent research from the United States, "The observation that loss of orexin (hypocretin) neurons causes human narcolepsy raises the possibility that other acquired disorders might also result from loss of hypothalamic neurons. To test this possibility for body weight, mice with selective loss of melanin concentrating hormone (MCH) neurons were generated."
T. Alon and colleagues working at Rockefeller University explained, "MCH was chosen to test because induced mutations of the MCH gene in mice cause hypophagia and leanness. Mice with ablation of MCH...
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