Obesity Therapy
Pyrrolo(Iso)quinoline derivatives reduce food intake in rats
Published in Obesity and Diabetes Week, March 6th, 2006
According to a study from England, "A series of 1-(1-pyrrolo(iso)quinolinyl)-2-propylamines was synthesized and evaluated as 5-HT2C receptor agonists for the treatment of obesity."
"The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand binding data for the compounds at 5-HT2 receptor subtypes are reported," explained D.R. Adams and colleagues, Vernalis Plc.
The researchers concluded, "The analogue which showed the highest 5-HT2C binding affinity (27, 1.6 nM) was found to be...
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