Obesity & Diabetes Week
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Complementary & Alternative Medicine
High-dose biotin may increase in guanylate cyclase activity and be diabetes therapy option
March 6th, 2006
CGMP may have trophic effects on beta cell function comparable to those of cAMP, and high-dose biotin may be an option for diabetes therapy. According to recent research published in the journal Medical Hypotheses, "Incretin hormones have trophic effects on beta cell function that can aid prevention and treatment of diabetes. cAMP is the primary mediator of these effects, and has been shown to potentiate glucose-stimulated insulin secretion, promote proper beta cells differentiation by increasing expression of the crucial transcription factor PDX-1, and prevent beta cell apoptosis. cGMP's role in beta cell function has received far less scrutiny, but there is...
Source: Obesity & Diabetes Week (2006-03-06)
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