Obesity & Diabetes Week
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Diabetes Pathogenesis
Diet and genetic control of Glut-2 glycosylation mediates insulin and suppresses diabetes
March 6th, 2006
Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. "Pancreatic beta cell-surface expression of glucose transporter 2 (Glut-2) is essential for glucose-stimulated insulin secretion, thereby controlling blood glucose homeostasis in response to dietary intake. We show that the murine GlcNAcT-IVa glycosyltransferase is required for Glut-2 residency on the 0 cell surface by constructing a cell-type and glycoprotein-specific N-glycan ligand for pancreatic lectin receptors," investigators in the United States report. K. Ohtsubo and colleagues at the University of California San Diego found,...
Source: Obesity & Diabetes Week (2006-03-06)
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