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Obesity & Diabetes Week

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Diabetes Pathogenesis



Findings in diabetes pathogenesis provide new insights



March 6th, 2006

Reports from Japan, Sweden and Denmark highlight recent research on diabetes pathogenesis.

Study 1: Insulin signaling in bone marrow stroma PA6 cells differs from extramedullary adipocytes.

According to recent research from Japan, "The stromal MC3T3-G2/PA6 (PA6) cells from mouse clavaria did not require insulin for differentiation into mature adipose cells, although insulin is well known to play a key role in adipocyte differentiation. Large lipid droplets were observed in the cytoplasm of PA6 cells, and mRNA expression of the adipose specific proteins (aP2, PPAR gamma, C/EBP alpha, FAS, GLUT4, leptin, and adiponectin) as differentiation markers...


Source: Obesity & Diabetes Week (2006-03-06)

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