Diabetes Pathogenesis
New findings in the area of diabetes pathogenesis detailed
Published in Obesity and Diabetes Week, March 6th, 2006
Study 1: Expression of dystrophin-dystroglycan complex and syntrophin-nitric oxide synthase complex may control insulin resistance in diabetic skeletal muscles.
"The inability of insulin to stimulate glucose metabolism in skeletal muscle fibers is a classic characteristic of type 2 diabetes. Using the nonobese Goto-Kakizaki rat as an established animal model of this type of diabetes, sucrose gradient centrifugation studies were performed and confirmed the abnormal subcellular location of the glucose transporter GLUT4. In addition, this...
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