Obesity & Diabetes Week
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Diabetes Pathogenesis
Nnt mutations uncouple beta cell mitochondrial metabolism leading to impaired insulin secretion
March 6th, 2006
Nnt mutations/deletion uncouple beta cell mitochondrial metabolism leading to impaired insulin secretion. "The C57BL/6J mouse displays glucose intolerance and reduced insulin secretion. QTL mapping identified nicotinamide nucleotide transhydrogenase (Nnt), a nuclear-encoded mitochondrial protein thought to be involved in free radical detoxification, as a candidate gene," investigators in England report. H. Freeman and colleagues working with the Medical Research Council described, "To investigate its functional role, we used siRNA to knockdown Nnt in insulin-secreting MIN6 cells. This produced a dramatic reduction in insulin secretion and the rise in...
Source: Obesity & Diabetes Week (2006-03-06)
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