Obesity & Diabetes Week
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Diabetes Pathogenesis
Oscillations of cAMP in hormone-stimulated insulin-secreting beta-cells were evaluated
March 6th, 2006
Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells were evaluated. "Cyclic AMP is a ubiquitous second messenger that transduces signals from a variety of cell surface receptors to regulate diverse cellular functions, including secretion, metabolism and gene transcription. In pancreatic beta-cells, cAMP potentiates Ca2+-dependent exocytosis(1-3) and mediates the stimulation of insulin release exerted by the hormones glucagon and glucagon-like peptide-1 (GLP-1) (refs 4-6)," scientists writing in the journal Nature report. O. Dyachok and colleagues working with Uppsala University recounted, "Whereas...
Source: Obesity & Diabetes Week (2006-03-06)
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