Diabetes Pathogenesis
P13K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells
Published in Obesity and Diabetes Week, March 6th, 2006
"Stress signals that impair the function of the endoplasmic reticulum (ER) can lead to an accumulation of unfolded proteins in the ER causing cell death. Recent studies have indicated that ER stress contributes to several diseases such as neurodegenerative disorders or diabetes," scientists in Japan report.
"In the present study," determined K. Hyoda and colleagues, Hokkaido University, "we found that Akt downregulation is important for inducing CHOP expression, an ER stress-induced transcription factor. Treatment with tunicamycin or thapsigargin, ER stress...
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