Obesity & Diabetes Week
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Diabetes Pathogenesis
Reports describe recent advances in diabetes pathogenesis research
March 6th, 2006
Data on diabetes pathogenesis are outlined in reports from Mexico, the South Korea and Italy. Study 1: Hyperglycemia induces apoptosis and p53 mobilization to mitochondria in RINm5F cells. "The mechanisms related to hyperglycemia-induced pancreatic beta-cell apoptosis are poorly defined. Rat insulin-producing cells (RINm5F) cultured in high glucose concentrations (30 mM) showed increased apoptosis and protein p53 translocation to mitochondria," scientists in Mexico report. "In addition," remarked C. Ortega-Camarillo and colleagues, Unidad de Investigacion Medica en Bioquimica, "hyperglycemia induced both the disruption of...
Source: Obesity & Diabetes Week (2006-03-06)
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