Obesity & Diabetes Week
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Diabetes Pathogenesis
Studies describe new findings in diabetes pathogenesis research
March 6th, 2006
Investigators in the United States, India and People's Republic of China have published new diabetes pathogenesis data. Study 1: A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 knockout. "We detected insulin 2 mRNA but not insulin 1 in thymus using real-time PCR analysis. Transgenic expression of a mutated insulin message (alanine rather than tyrosine at insulin B chain amino acid 16) was variably induced in thymus of four transgenic founder strains," investigators in the United States report. M. Nakayama and colleagues at the University of Colorado determined, "The transgenic...
Source: Obesity & Diabetes Week (2006-03-06)
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