Obesity & Diabetes Week
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Diabetes Therapy
Insulin action in brain contributes to glucose lowering during insulin treatment
March 6th, 2006
Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. In a recently published study, investigators in the United States conducted a study "to investigate the role of brain insulin action in the pathogenesis and treatment of diabetes, we asked whether neuronal insulin signaling is required for glucose-lowering during insulin treatment of diabetes." R.W. Gelling and colleagues at the University of Washington found, "Hypothalamic signaling via the insulin receptor substrate-phosphatidylinositol 3-kinase (IRS-PI3K) pathway, a key intracellular mediator of insulin action, was reduced in rats with uncontrolled...
Source: Obesity & Diabetes Week (2006-03-06)
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