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Diet & Nutrition
AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats
March 6th, 2006
AICAR, an AMP-activated protein kinase activator, has protective effects on alcohol-induced fatty liver in rats. "Previous work with metformin has shown that this antidiabetic, agent improves nonalcoholic fatty liver in ob/ob mice. AMP-activated protein kinase (AMPK) is one of the major cellular regulators of lipid and glucose metabolism, and reportedly mediates the beneficial metabolic effects of metformin. In this study, we examined the effects of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), an AMPK activator, on an experimental model of ethanol-induced hepatic steatosis," scientists in Japan report. K. Tomita and colleagues at...
Source: Obesity & Diabetes Week (2006-03-06)
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