Obesity & Diabetes Week
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Obesity Pathogenesis
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
March 6th, 2006
CCR2 modulates inflammatory and metabolic effects of high-fat feeding leading to obesity. According to a study from the United States, "The C-C motif chemokine receptor-2 (CCR2) regulates monocyte and macrophage recruitment and is necessary for macrophage-dependent inflammatory responses and the development of atherosclerosis. Although adipose tissue expression and circulating concentrations of CCL2 (also known as MCP1), a high-affinity ligand for CCR2, are elevated in obesity, the role of CCR2 in metabolic disorders, including insulin resistance, hepatic steatosis, and inflammation associated with obesity, has not been studied." S.P. Weisberg and...
Source: Obesity & Diabetes Week (2006-03-06)
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