Diabetic Neuropathy
Hyperglycemia-induced diabetic neuropathy reversed by GDNF activation of PI3K/Akt pathway
Published in Obesity and Diabetes Week, March 27th, 2006
"Diabetes can result in loss of enteric neurons and subsequent gastrointestinal complications. The mechanism of enteric neuronal loss in diabetes is not known. We examined the effects of hyperglycemia on enteric neuronal survival and the effects of glial cell line-derived neurotrophic factor (GDNF) on modulating this survival," scientists in the United States report.
M. Anitha and colleagues at Emory University found, "Exposure of primary enteric neurons to 20 mM glucose (hyperglycemia) for 24 hours...
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