Diabetes Complications
HNF-1 beta mutations result in reduced insulin sensitivity of endogenous glucose production
Published in Obesity and Diabetes Week, April 3rd, 2006
According to recent research from England, "Heterozygous mutations in the transcription factors hepatocyte nuclear factor (HNF)-1 alpha and -1 beta result in MODY (maturity-onset diabetes of the young). Despite structural similarity between HNF-1 alpha and -1 beta, HNF-1 beta mutation carriers have hyperinsulinemia, whereas HNF-1 alpha mutation carriers have normal or reduced insulin concentrations."
A. Brackenridge and colleagues at the University of Surrey assessed "whether HNF-1 beta mutation...
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