Insulin Resistance
Hyperphagia may be mediated by developmental perturbations in insulin signaling
Published in Obesity and Diabetes Week, April 3rd, 2006
"The onset of hyperphagia in the Zucker fatty (fa/fa) rat occurs on a single day in postnatal development and could be driven by an increase in insulin sensitivity. To test this hypothesis, we performed insulin tolerance tests at several points in development," scientists in the United States report.
H.A. Durham and colleagues at the University of Tennessee discovered, "In rapidly growing juvenile rats, fatty rats are as insulin sensitive as lean rats at 4 wk of age but become increasingly insulin resistant as they became obese. During the...
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