Cancer Research
High leptin receptor mRNA expression and leptin levels in breast cancer predicts poor outcome
Published in Obesity and Diabetes Week, April 10th, 2006
"The association of mRNA expression levels of leptin receptors (long isoform: Lep-R(L) and short isoform: Lep-R(S)) in breast cancer tissue with patient prognosis was studied with special reference to the serum leptin level or the leptin mRNA level in tumor tissue. Lep-R(L), Lep-R(S) and leptin mRNA levels in breast cancer tissue (n=91) were determined with a real-time PCR assay, and serum leptin levels in breast cancer patients (n=67) with an enzyme-linked immunosorbent assay," researchers in Japan report.
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