Obesity Pathogenesis
POMC variant implicates beta-MSH in the control of human energy balance
Published in Obesity and Diabetes Week, April 10th, 2006
"The melanocortin-4 receptor (MC4R) plays a critical role in the control of energy balance. Of its two pro-opiomelanocortin (POMC)-derived ligands, alpha-and beta-MSH, the majority of attention has focused on alpha-melanocyte-stimulating hormone (MSH), partly reflecting the absence of beta-MSH in rodents," investigators in England report.
Y.S. Lee and colleagues working with the University of Cambridge described, "We screened the POMC gene in 538 patients with severe, early-onset obesity and identified five unrelated probands who were heterozygous...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Obesity and Diabetes Week
More Articles from Obesity and Diabetes Week
- Endocrinology
Ghrelin secretion is lower in obese, but responds equally to oral glucose in obese and lean - Obesity Complications
Carotid artery stiffness and C-reactive protein were linked to metabolic syndrome in obese - Obesity Complications
Macrophage-secreted factors influence inflammatory and insulin responses in adipocytes - Obesity Epidemiology
Obesity related to insulin resistance adaptation mechanisms are similar across ethnic groups - Obesity Epidemiology
PPARGC1A Gly482Ser polymorphism is linked to high obesity risk in physically inactive - Angiology
Artery stiffness may be predicted by carotid-femoral pulse wave velocity and carotid stiffness - More from this issue of Obesity and Diabetes Week
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
