Obesity Pathogenesis
Notch most likely blocks adipogenesis through the induction of Hes-1 homodimers
Published in Obesity and Diabetes Week, April 17th, 2006
According to recent research from the United States, "Notch signaling blocks differentiation of 3T3-L1 preadipocytes, and this can be mimicked by constitutive expression of the Notch target gene Hes-1. Although considered initially to function only as a repressor, recent evidence indicates that Hes-1 can also activate transcription."
"We show here," proposed D.A. Ross and colleagues, University of Pennsylvania, "that the domains of Hes-1 needed to block adipogenesis coincide with those necessary for transcriptional repression. HRT1, another basic-helix-loop-helix protein...
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