Peripheral Vascular Disease
Therapeutic angiogenesis falls short in ischemic limbs deprived of CD34-positive cells
Published in Obesity and Diabetes Week, April 17th, 2006
"Autologous transplantation of granulocyte colony-stimulating factor (G-CSF)-mobilized human peripheral blood mononuclear cells (PBMNCs) improves limb ischemia in patients with arteriosclerosis obliterans of lower extremities and with diabetic foot. However, the mechanism of action of PBMNCs remains elusive," investigators in the People's Republic of China report.
"Here, we studied comparatively the effects of the G-CSF-mobilized PBMNCs and CD34-depleted G-CSF-mobilized PBMNCs in an ischemia model of athymic nude mice. Fluorescence-labeled human PBMNCs [1 x...
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