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Chronic high-fat and high-sucrose diets differentially affect glucose intolerance in mice

Published in Obesity and Diabetes Week, April 17th, 2006

Chronic intake of high-fat and high-sucrose diets differentially affects glucose intolerance in mice.

"Intakes of some macronutrients can comprise risk factors for life-style-related diseases such as obesity, hyperlipidemia, diabetes, hypertension, and atherosclerosis. In this study, we examined the effects in C57BL/6J mice of consuming excess fat or sucrose for a long period of time (55 wk). Another group of mice consumed a low-fat, low-sucrose (ILL) diet," investigators in Japan report.

M. Sumiyoshi and colleagues at Ehime University determined, "Mice fed the high-fat (HF) diet gained weight and developed hyperlipidemia and hyperleptinemia. At 25...

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